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Is Acupuncture Safe? By Brian B. Carter, MS, LAc, Thu Dec 8th
Acupuncture is much safer than most western medical treatments. To support that statement, I will cite such phenomenallycredible sources as: The National Institutes of Health (NIH) The Journal of theAmerican Medical Association (JAMA) - several places The Foodand Drug Administration (FDA)'s Center for Drug Evaluation andResearch (CDER) The British Medical Journal (BMJ) The AmericanSociety of Health-System Pharmacists 7 peer-reviewed medicaljournals found on the National Library of Medicine's MedLineStudies of data from malpractice claims Retrospective studies(from America and the U.K.) of more than 100,000 acupuncturetreatments
First I will discuss issues of safety. Then, I will bring out some issues in western medicine safety...just to give you a sense of the comparison between the two. The National Institutes of Health Consensus Statement onAcupuncture In 1997, the National Institutes of Health issued aconsensus statement on which said, among otherthings: "One of the advantages of is that the incidence ofadverse effects is substantially lower than that of many drugsor other accepted medical procedures used for the sameconditions. As an example, musculoskeletal conditions, such asfibromyalgia, myofascial pain, and tennis elbow, orepicondylitis, are conditions for which may bebeneficial. "These painful conditions are often treated with, among otherthings, anti-inflammatory medications (aspirin, ibuprofen, etc.)or with steroid injections. Both medical interventions have apotential for deleterious side effects but are still widely usedand are considered acceptable treatments. The evidencesupporting these therapies is no better than that foracupuncture." - National Institutes of Health ConsensusStatement on Acupuncture, 1997 Did you get that? They said that aspirin, anti-inflammatories,and steroids have not been supported by scientific evidence anybetter than acupuncture. The Safety of in terms of Malpractice InsuranceClaims "In an analysis of data from malpractice insurers from1990 through 1996, Studdert and colleagues18 found that claimsagainst chiropractors, massage therapists, and acupuncturistsgenerally occurred less frequently and usually involved lesssevere injury than claims against medical doctors." - Phil B.Fontanarosa, MD; George D. Lundberg, MD - JAMA 1998 Retrospective Studies of Treatment Safety: TheFrequency and Types of Adverse Events in 55,291 AcupunctureTreatments 99.8% of is performed with no significant minoradverse events; "During these 5 years, a total of 76acupuncturists (13 preceptors and 63 interns) participated inthe study, and the total number of treatments was55291. A total of 64 adverse events were reported and included11 types of events... The most frequent adverse event wasfailure to remove needles after treatment; no sequelae(problems) occurred after removal of the needles. The secondmost common adverse event was dizziness, discomfort, orperspiration probably due to transient hypotension (low bloodpressure) associated with the treatment.... We may,therefore, reasonably conclude that serious adverse events inacupuncture treatment are uncommon in the practice of adequatelytrained acupuncturists... ." - Hitoshi Yamashita, Bac, HiroshiTsukayama, BA, Yasuo Tanno, MD, PhD, Kazushi Nishijo, PhD, JAMA Two September 2001 Studies of Safety in BritishMedical Journal discuss the details of just 43 minor adverseevents in 34,407 treatments; and only 91 minorevents in another 31,822 treatments. If combinedwith the other study above, that equals a total of 121,520treatments with 198 minor adverse events (only 0.16% incidence),and no pnemuothoraxes (collapsing of the lung- this wasconcluded to be extremely rare). - The British Medical Journal(BMJ) 2001 What's the worst that can happen from - and did it? The most serious adverse events possible with arepneumothorax (collapsing the lung due to puncture) andsepticemia (systemic infection of the blood by bacteria);"Instruction is given by both lectures and practical trainingand includes information about anatomically risky depth ofinsertion and use of aseptic procedure for puncturing... Mostimportant, no serious events such as pneumothorax, spinallesion, or infection were reported." - JAMA November 1998 ...Zero out of 55,291! But even just one would have meant only a0.002% chance of these occurring. The Safety of compared with that of Biomedicine: Antibiotic overuse leads to resistant super-bacteria. "Theprevalence of antibiotic-resistant bacteria in Taiwan is due tothe heavy use of antimicrobial agents in both animal husbandryand clinical practice over the past decades" - Int J AntimicrobAgents 2001 Sep) as well as intestinal flora imbalance(diarrhea, vaginal candidiasis). "Antibiotic
A comparative clinical study of the effects of the traditional chinese medicine jinniu capsules and lofexidine on acute heroin withdrawal symptoms. Conclusion: Jinniu capsules may be an effective and safe agent in the management of opiate withdrawal.
PMID: 19016185 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse) Antiviral drugs advisory committee (december 2) The committee will begin with a closed session from 8 a.m. to 10:30 a.m., to permit discussion and review of trade secret and/or confidential information. Following the closed session, from 10:30 a.m. to 5 p.m., the meeting will be open to the public. The committee will discuss the safety and efficacy of new drug application (NDA) 20-725, Creon (pancrelipase delayed-release capsules), Solvay Pharmaceuticals, Inc., for the treatment of exocrine pancreatic insufficiency. (Source: Food and Drug Administration--Upcoming Meetings) A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of rhodiola rosea in the treatment of subjects with stress-related fatigue Planta MedDOI: 10.1055/s-0028-1088346AbstractThe aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of L. in the treatment of individuals suffering from stress-related fatigue. The phase III clinical trial took the form of a randomised, double-blind, placebo-controlled study with parallel groups. Participants, males and females aged between 20 and 55 years, were selected according to the Swedish National Board of Health and Welfare diagnostic criteria for fatigue syndrome. A total of 60 individuals were randomised into two groups, one ( = 30) of which received four tablets daily of SHR-5 extract (576 mg extract/day), while a second ( = 30) received four placebo tablets daily. The effects of the extract with respect to qualit... Mri monitoring of cartilage repair in the knee: a review Semin Musculoskelet Radiol 2008; 12: 302-317DOI: 10.1055/s-0028-1100638ABSTRACTVarious treatment options for deep cartilage defects are presently available. The efficacy of bone marrow stimulation with microfracture, of mosaicplasty and of various autologous chondrocyte implantation (ACI) techniques has been subject to numerous studies recently. Magnetic resonance imaging (MRI) has gained a major role in the assessment of cartilage repair. The introduction of high-field MRI to clinical routine makes high resolution and three-dimensional imaging readily available. New quantitative MRI techniques that directly visualize the molecular structure of cartilage may further advance our understanding of cartilage repair. The clinical evaluation of cartilage repair tissue is a complex issue, and MR ... Induction chemotherapy in locally advanced head and neck cancer: a new standard of care? Authors: Lorch JH, Posner MR, Wirth LJ, Haddad RI
Locally advanced squamous cell cancer of the head and neck is a major contributor to morbidity and mortality worldwide. Despite progress through the use of multimodality treatment involving surgery, radiotherapy, and chemotherapy in recent years, the survival remains poor, and treatment-related morbidity-mainly caused by radiation-induced effects such as soft tissue scarring, esophageal stenosis, xerostomia, dental decay, and osteoradionecrosis-is a major problem in long-term survivors. Data from early trials and encouraging results from meta-analyses have revived interest in the use of neoadjuvant or induction chemotherapy before definitive local treatment. Recent randomized trials have demonstrated marked improvements in survival with... Innovation in the surgical management of head and neck tumors. Authors: Gilbert RW
The surgical management of head and neck tumors continues to evolve with a focus on reducing treatment-related morbidity. The major changes in the past two decades have been the introduction of function-preserving, minimally invasive surgical approaches and a dramatic change in the ability to reconstruct ablative defects and restore form and function. The future certainly will include better evidence regarding the efficacy and appropriate application of these new techniques. Reconstructive techniques will continue to evolve with introduction of tissue engineering and cell therapy to further improve the quality of life of patients afflicted with head and neck malignancies.
PMID: 19010267 [PubMed - in process] (Source: Hematology/Oncology Clinics of North America) The efficacy of echocardiographic criterions for the diagnosis of carditis in acute rheumatic fever Research ArticlesIshwarappa B. Vijayalakshmi, Rajan O. Vishnuprabhu, Narasimhan Chitra, Ravindra Rajasri, Thejoor V. Anuradha, Cardiology in the Young, Volume 18 Issue 06 , pp 586-592AbstractBackground There is a great need for echocardiographic criterions for accurate diagnosis of carditis in acute rheumatic fever. (Source: Cardiology in the Young) Acp guideline finds no substantial differences among “second-generation” antidepressants New guideline looks at effectiveness of drugs used to treat depressive disorders
PHILADELPHIA--(BUSINESS WIRE)--No substantial differences in efficacy or quality of life were found among “second-generation” antidepressants used to treat... (Source: Drugs.com - Pharma News) Overeating: it?s all in your head Pages: 1 2 3 4 Next » The following is an excerpt from the book Three Minute Therapy and focuses on the topic of overeating and how cognitive-behavioral techniques can be used to help a person overcome this concern.
They say that inside every fat person there’s a thin person fighting to get out. In Suzie’s case, the thin person appeared to be losing the struggle. At 5′4″ Suzie felt she ought to be 130 lbs, but was actually closer to 160.
Just about to turn 20, Suzie looked older. She had deep eyes and smooth chestnut hair beneath her floppy leghorn hat, and wore a silk print dress with an enormous string of crystal beads. She had a lively manner and was ready to laugh, but seemed imprisoned by her excess fat. She was disheartened. “I’ve tried do... American college of physicians finds no substantial differences among "second-generation" antidepressant drugs The American College of Physicians is publishing a new guideline for the treatment of depression in Annals of Internal Medicine. ACP found no substantial differences in efficacy or quality of life among "second-generation" antidepressants used to treat depressive disorders such as major depressive disorder. (Source: Health News from Medical News Today) In vivo model for human brain cancer (human glioblastoma gbm) for drug discovery applications introduced by celprogen Celprogen Inc., a Global leader in the Stem Cell Research and Therapeutics industry for development of stem cell technologies in regenerative medicine, today announced that they have successfully validated an in vivo model system for testing efficacy of cancer drugs and also novel drug candidates for Human Glioblastoma. (Source: Health News from Medical News Today) Antibiotic mechanism revealed by biomedical engineers' detective work A series of genetic clues led a team of Boston University biomedical engineers to uncover exactly how certain antibiotics kill bacteria. The findings could help rejuvenate the efficacy of older antibiotics and reveal new antibiotic targets within bacterial cells. (Source: Health News from Medical News Today) American college of physicians: american college of physicians finds no substantial differences among "second-generation" antidepressant drugs PHILADELPHIA, PA (MARKET WIRE) The American College of Physicians is publishing a new guideline for the treatment of depression in Annals of Internal Medicine. ACP found no substantial differences in efficacy or quality of life among "second-generation" antidepressants used to treat depressive disorders such as major depressive disorder. ACP recommends that physicians make treatment decisions based on side effects, cost, and patient preferences, and make necessary changes in therapy if the response is not sufficient after six to eight weeks. Doctors should also assess patient status and adverse effects on a regular basis (Source: Market Wire - Pharmaceuticals and Biotech) Africa: bed net usage increases, but millions of african children still exposed to malaria The use of insecticide-treated bed nets (ITNs) to protect children from malaria has risen six-fold in the past seven years, according to research funded by the Welcome Trust. Despite this success, however, 90 million children still do not have access to this simple protective tool, and remain at risk from the life-threatening disease. (Source: AllAfrica News: Malaria) Relapsing-remitting multiple sclerosis - teva completes enrollment in laquinimod phase iii clinical trial Teva Pharmaceutical Industries Ltd. (NASDAQ: TEVA) and Active Biotech (NASDAQ OMX NORDIC: ACTI) today announced completion of patient enrollment for the Phase III clinical trial, Allegro, in relapsing-remitting multiple sclerosis (RRMS). The pivotal Allegro study is designed to evaluate the efficacy, safety and tolerability of the oral investigational compound, laquinimod, versus placebo in the treatment of RRMS. (Source: Multiple Sclerosis News From Medical News Today) 90 million african children still exposed to malaria, despite net usage increase The use of insecticide-treated bed nets (ITNs) to protect children from malaria has risen six-fold in the past seven years, according to research funded by the Wellcome Trust. Despite this success, however, 90 million children still do not have access to this simple protective tool, and remain at risk from the life-threatening disease. Malaria kills nearly a million people in Africa every year. (Source: Tropical Diseases News From Medical News Today) Vernakalant (rsd1235) in the management of atrial fibrillation: a review of pharmacological properties, clinical efficacy and safety Future Cardiology , November 2008, Vol. 4, No. 6, Pages 559-567.
Vernakalant (RSD1235) is a novel antiarrhythmic agent for conversion of rapid onset atrial fibrillation (AF). It is an atria-selective multichannel ion blocker (blocks IKur, INa, ICa, L, Ito and IKr), with a small effect on ventricular repolarization. In ... (Source: Future Cardiology) Performance and population analysis of a non-sterile trickle bed reactor inoculated with caldicellulosiruptor saccharolyticus, a thermophilic hydrogen producer Non-axenic operation of a 400 L trickle bed reactor inoculated with the thermophile Caldicellulosiruptor saccharolyticus, yielded 2.8 mol H2/mol hexose converted. The reactor was fed with a complex medium with sucrose as the main substrate, continuously flushed with nitrogen gas, and operated at 73°C. The volumetric productivity was 22 mmol H2/(L filterbed h). Acetic acid and lactic acid were the main by-products in the liquid phase. Production of lactic acid occurred when hydrogen partial pressure was elevated above 2% and during suboptimal fermentation conditions that also resulted in the presence of mono- and disaccharides in the effluent. Methane production was negligible. The microbial community was analyzed at two different time points during operation. Initially, other species rela... [original articles] a randomised controlled trial on whether a participatory ergonomics intervention could prevent musculoskeletal disorders Conclusions:
The intervention did not reduce perceived physical work load and no evidence was found for the efficacy of the intervention in preventing musculoskeletal disorders among kitchen workers. It may be that a more comprehensive redesign of work organisation and processes is needed, taking more account of workers’ physical and mental resources. (Source: Occupational and Environmental Medicine) [clinical synthesis] quick reference panic and social anxiety disorder: applications of individual cognitive-behavioral therapy to specific disorders efficacy and indications Source: Epp AM, Dobson KS, Cottraux J: Applications of Individual Cognitive-Behavioral Therapy to Specific Disorders in Textbook of Psychotherapeutic Treatments. Edited by Gabbard GO, Washington DC, American Psychiatric Publishing Inc. 2009 p239–247 Excerpted and Reprinted with permission. (Source: FOCUS) [influential publications] a randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder Conclusions: Despite the small cohort size of this trial, it has demonstrated preliminary efficacy of panic-focused psychodynamic psychotherapy for panic disorder.
(Reprinted with permission from American Journal of Psychiatry 2007; 164:265–272) (Source: FOCUS) [immunology] profiling antibody responses by multiparametric analysis of primary b cells Determining the efficacy of a vaccine generally relies on measuring neutralizing antibodies in sera. This measure cannot elucidate the mechanisms... (Source: Proceedings of the National Academy of Sciences) [medical_sciences] in vivo efficacy of the bcl-2 antagonist abt-737 against aggressive myc-driven lymphomas Deregulated Myc expression drives many human cancers, including Burkitt's lymphoma and a highly aggressive subset of diffuse large cell lymphomas.... (Source: Proceedings of the National Academy of Sciences) A randomized trial to monitor the efficacy and effectiveness by qt-nasba of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated plasmodium falciparum malaria in western kenya Conclusions:
Although practical considerations could favour the use of one drug over another, the effect on gametocytogenesis should also be taken into account and studied further using molecular tools like NASBA. This also applies when a new drug is introduced.
Trial registration
Current controlled trials ISRCTN36463274 (Source: BioMed Central) Gene therapy for inborn errors of liver metabolism: progress towards clinical applications This article summarizes the gene transfer strategies being investigated, the pre-clinical data, and the available early clinical results for inborn errors of liver metabolism. (Source: BioMed Central) Long-term production of soluble human fas ligand through immobilization of dictyostelium discoideum in a fibrous bed bioreactor. Long-term production of soluble human Fas ligand through immobilization of Dictyostelium discoideum in a fibrous bed bioreactor.
Appl Microbiol Biotechnol. 2008 Nov 18;
Authors: Chen J, Chen H, Zhu X, Lu Y, Yang ST, Xu Z, Cen P
The production of recombinant glycoproteins in Dictyostelium discoideum by conventional cell culture methods was limited by low cell density as well as low growth rate. In this work, cotton towel with a good adsorption capability for D. discoideum cells was used as the immobilization matrix in an external fibrous bed bioreactor (FBB) system. With batch cultures in the FBB, the concentration of immobilized cells in the cotton fiber carrier increased to 1.37 x 10(8) cells per milliliter after 110-h cultivation, which was about tenfold higher than the maxim... Parent-assisted social skills training to improve friendships in teens with autism spectrum disorders. This study examines the efficacy of a manualized parent-assisted social skills intervention in comparison with a matched Delayed Treatment Control group to improve friendship quality and social skills among teens 13-17 years of age with autism spectrum disorders. Targeted skills included conversational skills, peer entry and exiting skills, developing friendship networks, good sportsmanship, good host behavior during get-togethers, changing bad reputations, and handling teasing, bullying, and arguments. Results revealed, in comparison with the control group, that the treatment group significantly improved their knowledge of social skills, increased frequency of hosted get-togethers, and improved overall social skills as reported by parents. Possibly due to poor return rate of questionnaire... Internist group finds no efficacy difference among modern antidepressants PHILADELPHIA (MedPage Today) -- Second-generation antidepressants all have similar efficacy, so physicians should base their medication choices for depressed patients on side effects, cost, and patient response, according to a new practice guideline from the American College of Physicians. (Source: MedPage Today Psychiatry) Phase ii study of temozolomide and thalidomide in patients with unresectable or metastatic leiomyosarcoma In conclusion, this combination of temozolomide and thalidomide provided disease stabilization in a subset of patients with advanced leiomyosarcoma. We hypothesize that temozolomide is the active agent in this regimen, and should be further studied. (Source: Sarcoma) Novel anti-angiogenic therapies for malignant gliomas. Authors: Norden AD, Drappatz J, Wen PY
BACKGROUND: Despite optimum treatment with surgery, radiation therapy, and chemotherapy, most patients with malignant glioma have a poor prognosis. Malignant gliomas are vascular tumours that produce vascular endothelial growth factor (VEGF), which is an important mediator of angiogenesis. Preclinical data indicate that angiogenesis is essential for the proliferation and survival of malignant glioma cells, which suggests that inhibition of angiogenesis might be an effective therapeutic strategy. Anti-angiogenic therapies that target VEGF and the VEGF receptor (VEGFR) are effective adjuncts to the treatment of solid tumours. Normalisation of dilated and leaky tumour vasculature might also enable anti-angiogenic therapy to increase the efficacy of r... Prevention of oxidative dna damage by bioactive berry components. In this study, ACI rats (8 wk old) were fed either AIN-93M diet or diets supplemented with 0.5% each of mixed berries (strawberry, blueberry, blackberry, and red and black raspberry), blueberry alone (BB; 2.5%), or ellagic acid (EA; 400 ppm) from 2 wk prior to and up to 12 wk of E(2) treatment. The liver DNA was analyzed for the presence of 8-oxo-7,8-dihydroguanine (8-oxodG) and other polar adducts by 32P-postlabeling. Compared to sham treatment, E(2) significantly increased the levels of both 8-oxodG and P-1 subgroup (259% and 214%, respectively; P< 0.05). EA diet significantly reduced E(2)-induced levels of 8-oxodG, P-1, P-2, and PL-1 by 79, 63, 44, and 67%, respectively (P< 0.001). BB diet also significantly reduced the levels of P-1, P-2, and PL-1 subgroups by 77, 43, and 68%, re... Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. We reported recently that GSE inhibits CRC cell HT29 growth in culture and nude mice xenograft. Because GSE is available commercially through different vendors, here we assessed whether GSE from 2 different manufacturers produces comparable biological effects in a panel of human CRC cell lines. Our results show that irrespective of source, GSE strongly inhibits LoVo, HT29, and SW480 cell growth, with a G1 arrest in LoVo and HT29 cells but an S and/or G2/M arrest in SW480 cell cycle progression. GSE also induced Cip/p21 levels in all 3 cell lines. Furthermore, an induction of apoptosis was observed in all 3 cell lines by GSE. Taken together, our findings suggest that GSE could be an effective CAM agent against CRC possibly due to its strong growth inhibitory and apoptosis-inducing effects.
... Overcoming immunologic tolerance to melanoma: targeting ctla-4 with ipilimumab (mdx-010). Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with ipilimumab (MDX-010).
Oncologist. 2008;13 Suppl 4:16-25
Authors: Weber J
Targeted biologic therapies such as anti-cytotoxic T lymphocyte antigen (CTLA-4) monoclonal antibodies, either as monotherapy or in combination with chemotherapy or vaccines, have shown great promise in late-stage melanoma, which has a very poor prognosis. Melanoma is relatively resistant to both chemotherapy and radiotherapy. Blockade of CTLA-4, which inhibits T-cell proliferation, promotes stimulation of adaptive immunity and T-cell activation, resulting in eradication of tumor cells. Two human monoclonal antibodies are under investigation in melanoma. Phase II and III clinical trials are currently evaluating the efficacy and safety of i... Medtronic completes enrollment ahead of schedule in key trial of endeavor(r) resolute drug-eluting stent Medtronic, Inc. (NYSE: MDT), announced today that enrollment in the 2,300-patient RESOLUTE All-Comers (R-AC) clinical study was completed in just six months, two months ahead of schedule. The randomized trial compares the safety and efficacy of Medtronic's Endeavor Resolute drug-eluting stent (DES) with Abbott Laboratories' XienceŽ DES. (Source: Cardiovascular / Cardiology News From Medical News Today) Modified irinotecan plus bolus 5-fluorouracil/l-leucovorin for metastatic colorectal cancer at a single institution in japan Conclusions Modified IFL therapy is an effective and well-tolerated regimen for Japanese patients with metastatic colorectal cancer. Modified
IFL therapy combined with biological agents might remain an option for some patients who refuse a central venous catheter.
Content Type Journal ArticleCategory Alimmentary TractDOI 10.1007/s00535-008-2242-1Authors
Mitsukuni Suenaga, Japanese Foundation for Cancer Research Department of Medical Oncology, Cancer Institute Hospital 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanNobuyuki Mizunuma, Japanese Foundation for Cancer Research Department of Medical Oncology, Cancer Institute Hospital 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanDaigo Shouji, Japanese Foundation for Cancer Research Department of Medical Oncology, Cancer Institute ... Substance in black pepper increases nutrient absorption up to two thousand percent (NaturalNews) Putting black pepper on your food may be one of the easiest, most economical ways to boost your overall health status. Piperine, the main alkaloid from black pepper has been shown to substantially increase the bioavailability of the nutrients in foods and supplements. As the quality of food declines and the costs of food and supplements continue to skyrocket, it is increasingly important to your health that the nutrients you consume are able to be used to maximum efficiency by your body.What is piperine?Piperine is a pungent compound found in the fruit of the plants in the Piperaceae family, the most famous member of which is Piper nigrum, black pepper. It has a long history of use in Ayurvedic medicine as a restorative and treatment.Piperine is able to increase bioavilabilit... Cancer drugs make tumors grow (NaturalNews) Drugs like Avastin that are used to treat some cancers are supposed to work by blocking a vessel growth-promoting protein called vascular endothelial growth factor, or VEGF. With VEGF held in check, researchers have assumed tumors wouldn't generate blood vessels and that should keep malignancies from growing. In a sense, the cancerous growths would be "starved". But new research just published in the journal Nature shows this isn't true. Instead of weakening blood vessels so they won't "feed" malignant tumors, these cancer treatments, known as anti-angiogenesis drugs, actually normalize and strengthen blood vessels -- and that means they can spur tumors to grow larger.For their study, researchers at the Moores Cancer Center at the University of California, San Diego (UCSD) in... Amphotericin b liposomal: lack of efficacy in disseminated saksenae vasiformis infection resulting in death: case report (Source: Reactions) Ivf and acupuncture Reducing the stress and anxiety women feel when undergoing in vitro fertilization (IVF) is considered important in improving the pregnancy rate in these women. (Source: Medical Headlines From Ivanhoe.com) Effect of foot orthoses on lower extremity kinetics during running: a systematic literature review. Conclusions:
The findings of this review demonstrate systematic effects that can be used to inform the direction of future research in this field, as further evidence is required to adequately define the mechanism of action of foot orthoses during running. Continuation of research in this field will enable targeting of design parameters towards biomechanical variables that are supported by evidence, and may lead to advancements in clinical efficacy. (Source: BMC Public Health - Latest articles) Growth hormone secretagogue mk-677: no clinical effect on ad progression in a randomized trial Conclusion: Despite evidence of target engagement as indicated by an increase in serum insulin-like growth factor-1, the human growth hormone secretagogue MK-677 25 mg was ineffective at slowing the rate of progression of Alzheimer disease. (Source: Neurology) Application of the transtheoretical model to identify aspects influencing condom use among korean college students Increasing condom use requires an understanding of the influencing factors. Previous research has used psychosocial theories such as the social cognitive theory and health belief to explain AIDS risk factors and condom use. However, it is still difficult to effectively predict the multidimensional factors associated with condom use. The present study utilizes the transtheoretical model to investigate condom use among college students by examining stages of change for condom use and measuring decisional balance and self-efficacy for each stage. The aim was to identify the variables affecting condom use so as to provide scientific data that would aid the development of effective strategies for increasing condom use. (Source: Western Journal of Nursing Research) Self-efficacy, outcome expectation, self-care behavior, and glycosylated hemoglobin level in persons with type 2 diabetes (Source: Western Journal of Nursing Research) Original article: efficacy of tympanoplasty without mastoidectomy for chronic suppurative otitis media Conclusions The success rate of tympanoplasty without mastoidectomy is at least as good for patients with CSOM as it is for patients with perforation without prior otorrhea. Age (P = .28), perforation size (P = .11), and surgical approach (P = .82) were not significantly related to success rate. Revision surgery was associated with a slightly lower success rate. (Source: Archives of Otolaryngology) Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now? (Source: Human Reproduction) Reproductive outcome after transplantation of ovarian tissue: a systematic review CONCLUSIONS
Transplantation of ovarian tissue can re-establish OVF after POF; however, the efficacy of OTT using cryopreserved tissues is not yet equivalent to that of fresh grafts. A controlled multicenter trial with sufficient follow-up would provide valid evidence of the potential benefit of this procedure. (Source: Human Reproduction) Study: clinical assessment of patients with recalcitrant psoriasis in a randomized, observer-blind, vehicle-controlled trial using indigo naturalis Conclusion Topical indigo naturalis ointment was a novel, safe, and effective therapy for plaque-type psoriasis. (Source: Archives of Dermatology) Observation: treatment of chronic leg ulcers with topical activated protein c Conclusions Activated protein C can stimulate wound healing in patients with skin ulcers that are refractory to conventional wound-healing therapies. The likely mechanism of action is its recognized ability to stimulate angiogenesis and reepithelialization and to inhibit inflammation. Activated protein C has potential as a therapeutic option for patients with chronic skin ulcers. (Source: Archives of Dermatology) The united kingdom expert patients programme: results and implications from a national evaluation. The United Kingdom Expert Patients Programme: results and implications from a national evaluation.
Med J Aust. 2008 Nov 17;189(10):21-4
Authors: Rogers A, Kennedy A, Bower P, Gardner C, Gately C, Lee V, Reeves D, Richardson G
The Expert Patients Programme (EPP) is a central element of chronic disease management policy in the United Kingdom. It aims to deliver self-care support by developing peoples' self-care skills, confidence and motivation to take more effective control over their long-term conditions. A large, national randomised controlled trial found that the EPP's lay-led skills training was effective in improving self-efficacy and energy levels among patients with long-term conditions, and was likely to be cost-effective. Key questions remain as to whether existing outc... Original article: gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway Conclusions Alvimopan, 12 mg, administered 30 to 90 minutes before and twice daily after bowel resection is well tolerated, accelerates GI tract recovery, and reduces postoperative ileus–related morbidity without compromising opioid analgesia.
Trial Registration clinicaltrials.gov Identifier: NCT00205842 (Source: Archives of Surgery)
use is a short-term risk factor for symptomaticvulvovaginal candidiasis, either as a first episode or in theform of recurrence. Increasing duration of antibiotic use isdirectly related with an increased prevalence of Candida vaginalinfection." - Am J Obstet Gynecol 1999 Jan "The spectrum of diarrheal disease associated with antibiotictherapy ranges from antibiotic associated diarrhea and colitis,to the more severe pseudomembranous colitis, which is alwaysassociated with Clostridium difficile (CD)." - ActaGastroenterol Latinoam 1996 The FDA approves unsafe drugs if they are effective enough. "No drug product is "perfectly" safe. Every single drug thataffects the body will have some side effects. Since the FDAconsiders both the benefits and risks of all medications beforeapproval, side effects are generally not serious. For every drugFDA approves, the benefits are balanced against its risks. Inaddition, FDA makes sure the labeling (package insert) outlinesthe benefits and risks reported in the tested population. Youand your health-care provider should decide together if thebenefits outweigh the risks for YOU. Talking about yourmedicines with your health-care provider is just as importantand good for your health as a complete check-up and taking yourmedicine as directed." - Frequently asked questions from theCenter for Drug Evaluation and Research (CDER) at the FDA "The benefit-risk ratio weighs the benefits provided by a drug,versus risks or safety problems that may be associated with useof the drug. No drug can be considered to be totally safe. Drugsthat are associated with more significant safety problems areexpected to have sufficiently greater benefits to justify theincreased risk." - Questions and Answers from CDER'sOver-the-Counter Drug Products Public Hearing (FDA) What does benefit-risk mean to us? "There are categories that, from my perspective, clearly fallout where the benefits unequivocally outweigh the risks... Ithink physicians very frequently discuss risk-benefit ratios forall sorts of treatments, and it ultimately comes down to adecision between the patient and the doctor." - Questions andAnswers from CDER's Over-the-Counter Drug Products PublicHearing (FDA) Adverse drug reactions (ADRs): Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen"Gastrointestinal (GI) Adverse Drug Reactions (ADRs) from the+NSAIDs are a major cause of morbidity and mortality inarthritic patients taking these drugs... Clearly, the need todevelop newer NSAIDs with lower risks of ulcers and bleeding aswell as symptomatic ADRs is still representing a majorchallenge." - J Physiol Paris 2001 High dosage Steroid use (e.g. in Asthma or COPD) "High dose ofinhaled steroids may lead to adrenocortical suppression andhence estrogen deficiency in postmenopausal women" - J AllergyClin Immunol 1989 Feb "the daily dose, but not the duration, of inhaled steroidtherapy may adversely affect bone density" (osteoporosis) - JAllergy Clin Immunol 1995 Aug "The potential risks of antiasthmatic inhaled steroid therapyare essentially dose-related and include oropharyngealcomplications such as: thrush and dysphonia, and systemic complications such ashyperactivity behavioural change hypothalamic-pituitary-adrenalaxis suppression facial and weight changes characteristic ofhypercortisonism cataracts increased intraocular pressure dermalatrophy causing steroid purpura retarded growth in children andosteoporosis. A few cases of fracture or acute adrenocorticalinsufficiency have been reported." - Can Respir J 1998 This last article is subtitled "First do no harm" after theHippocratic Oath taken by most MD's. Drug Misadventures: "Still, we know from studies published todate that drug misadventures account for: 8-10% of admissions ofpatients to hospitals 25% of admissions to hospitals by personsage 65 years of age or older 10-15% of visits to emergency roomsin some urban settings 4.5 drug order errors per 1000 drugorders in hospitals Significant decreases in the quality of life(due to inappropriate prescribing, e.g., of hypnotics for theelderly) 2 in 1000 deaths in hospitals, and Deterioration ordestruction of specific organs." - from "Toward defining andapplying a higher standard of quality for medication use in theUnited States" from the American Society of Health-SystemPharmacists So in summary, it's clear that no medicine is totally safe.Except perhaps prayer! Hopefully the comparison above is telling- the risks of mostwestern medical interventions are greater than in acupuncture. So, I ask you- if it works and it's safer, why is it an"alternative"? About the author:Acupuncturist, herbalist, and medical professor Brian B. Carterfounded the alternative health megasite The Pulse of OrientalMedicine (http://www.PulseMed.org/). He is the author of thebook "Powerful Body, Peaceful Mind: How to Heal Yourself withFoods, Herbs, and Acupressure" (November, 2004). Brian speaks onradio across the country, and has been quoted and interviewed byReal Simple, Glamour, and ESPN magazines. |
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